| Gene |
Kcnma1
|
| Protein Name |
KCMA1_MOUSE |
| Organism |
Mus musculus (Mouse) |
| Alternative name(s) |
Calcium-activated potassium channel subunit alpha-1 (BK channel) (BKCA alpha) (Calcium-activated potassium channel, subfamily M subunit alpha-1) (K(VCA)alpha) (KCa1.1) (Maxi K channel) (MaxiK) (Slo-alpha) (Slo1) (mSlo1) (Slowpoke homolog) (Slo homolog) (mSlo) |
| Protein Family |
Potassium channel family |
| NCBI Gene ID |
16531
|
| UniProt ID |
Q08460
|
| Enzyme Class |
- |
| Molecular Weight |
134396 |
| Protein Length |
1209 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Cell membrane |
| Function (UniProt annotation) |
Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. In smooth muscles, its activation by high level of Ca(2+), caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. In cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. Kinetics of KCNMA1 channels are determined by alternative splicing, phosphorylation status and its combination with modulating beta subunits. Highly sensitive to both iberiotoxin (IbTx) and charybdotoxin (CTX). |
| Gene Ontology |
GO:0001666; GO:0003779; GO:0005249; GO:0005267; GO:0005737; GO:0005783; GO:0005886; GO:0005901; GO:0006813; GO:0006970; GO:0007268; GO:0007605; GO:0007623; GO:0007628; GO:0008076; GO:0009268; GO:0009897; GO:0015269; GO:0015271; GO:0016021; GO:0016324; GO:0019228; GO:0030007; GO:0030425; GO:0031960; GO:0032344; GO:0032991; GO:0034465; GO:0034765; GO:0042311; GO:0042391; GO:0042491; GO:0042802; GO:0042803; GO:0043025; GO:0043065; GO:0043195; GO:0043525; GO:0043627; GO:0044877; GO:0045211; GO:0045475; GO:0045794; GO:0046541; GO:0046872; GO:0048469; GO:0048471; GO:0048787; GO:0050885; GO:0051260; GO:0051289; GO:0051592; GO:0060072; GO:0060073; GO:0060082; GO:0060083; GO:0060087; GO:0097746; GO:0097755; GO:0098978; GO:0099059; GO:1904348 |
