| Gene |
PPP2R5C
|
| Protein Name |
2A5G_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (PP2A B subunit isoform B'-gamma) (PP2A B subunit isoform B56-gamma) (PP2A B subunit isoform PR61-gamma) (PP2A B subunit isoform R5-gamma) (Renal carcinoma antigen NY-REN-29) |
| Protein Family |
Phosphatase 2A regulatory subunit B56 family |
| NCBI Gene ID |
5527
|
| UniProt ID |
Q13362
|
| Enzyme Class |
- |
| Molecular Weight |
61061 |
| Protein Length |
524 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Nucleus. Chromosome, centromere. |
| Function (UniProt annotation) |
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation. |
| Gene Ontology |
GO:0000159; GO:0000775; GO:0005634; GO:0005654; GO:0005794; GO:0005829; GO:0006977; GO:0007165; GO:0008285; GO:0014066; GO:0019888; GO:0031952; GO:0042771; GO:0043161; GO:0072542 |
