| Gene |
EIF4EBP1
|
| Protein Name |
4EBP1_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) (eIF4E-binding protein 1) (Phosphorylated heat- and acid-stable protein regulated by insulin 1) (PHAS-I) |
| Protein Family |
EIF4E-binding protein family |
| NCBI Gene ID |
1978
|
| UniProt ID |
Q13541
|
| Enzyme Class |
- |
| Molecular Weight |
12580 |
| Protein Length |
118 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
N/A |
| Function (UniProt annotation) |
Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways. |
| Gene Ontology |
GO:0000082; GO:0002192; GO:0005737; GO:0005829; GO:0008190; GO:0008286; GO:0030371; GO:0031929; GO:0045931; GO:0045947; GO:0071549 |
