CaMKinet | Result

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Sequence Viewer

Parameter	Value
Gene	RIPK1
Protein Name	RIPK1_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Cell death protein RIP) (Receptor-interacting protein 1) (RIP-1)
Protein Family	Protein kinase superfamily
NCBI Gene ID	8737
UniProt ID	Q13546
Enzyme Class	2.7.11.1
Molecular Weight	75931
Protein Length	671
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	ATP + a protein = ADP + a phosphoprotein.
Localization	Cytoplasm. Cell membrane
Function (UniProt annotation)	Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage (PubMed:11101870, PubMed:17389591, PubMed:19524512, PubMed:19524513). Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor (PubMed:11101870, PubMed:17389591, PubMed:19524512, PubMed:19524513). Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade (PubMed:17389591). Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules (PubMed:15258597). Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death (PubMed:15258597). RIPK1 and RIPK3 association, in particular, forms a necrosis-inducing complex (PubMed:19524513, PubMed:19524512).
Gene Ontology	GO:0000165; GO:0001934; GO:0002756; GO:0004672; GO:0004674; GO:0004706; GO:0005123; GO:0005524; GO:0005739; GO:0005829; GO:0006915; GO:0006919; GO:0007249; GO:0007257; GO:0010008; GO:0010803; GO:0010940; GO:0016032; GO:0016579; GO:0031264; GO:0031625; GO:0032757; GO:0032760; GO:0033209; GO:0034138; GO:0034612; GO:0035666; GO:0036289; GO:0042802; GO:0043065; GO:0043068; GO:0043123; GO:0043124; GO:0043235; GO:0044257; GO:0044877; GO:0045121; GO:0045651; GO:0045944; GO:0046330; GO:0046777; GO:0051092; GO:0051260; GO:0051291; GO:0060545; GO:0070231; GO:0070266; GO:0070513; GO:0070926; GO:0071356; GO:0071363; GO:0071550; GO:0097190; GO:0097191; GO:0097342; GO:0097343; GO:0097527; GO:1901026; GO:1902041; GO:1902042; GO:1905206; GO:1990000; GO:2000379; GO:2001237; GO:2001238; GO:2001240

Gene Ontology

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
MAPKAPK2 (P49137)	Homo sapiens	S320	AVVKRMQSLQLDCVA	0.919	0.391	-	-	-	-	-	-	in-vitro and in-vivo

Interaction Network

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

No KEGG pathways found

No NCI Nature pathways found