CaMKinet | Result

Sequence Viewer

Parameter	Value
Gene	SLC12A1
Protein Name	S12A1_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	Solute carrier family 12 member 1 (Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2) (Kidney-specific Na-K-Cl symporter)
Protein Family	SLC12A transporter family
NCBI Gene ID	6557
UniProt ID	Q13621
Enzyme Class	-
Molecular Weight	121450
Protein Length	1099
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	-
Localization	Membrane; Multi-pass membrane protein.
Function (UniProt annotation)	Electrically silent transporter system. Mediates sodium and chloride reabsorption. Plays a vital role in the regulation of ionic balance and cell volume.
Gene Ontology	GO:0005886; GO:0006811; GO:0006884; GO:0008511; GO:0010107; GO:0015081; GO:0015378; GO:0015379; GO:0016020; GO:0016021; GO:0016324; GO:0034220; GO:0035725; GO:0055064; GO:0055075; GO:0070062; GO:1902476

Gene Ontology

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
PRKAA1 (Q13131)	Homo sapiens	S130	GPKVNRPSLLEIHEQ	0.603	0.3872	-	-	-	-	-	-	In vivo
PRKAA1 (Q13131)	Homo sapiens	S122	YRNTGSISGPKVNRP	0.201	0.3286	-	-	-	-	-	-	-

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

No KEGG pathways found

No NCI Nature pathways found