| Gene |
TRIM29
|
| Protein Name |
TRI29_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Tripartite motif-containing protein 29 (Ataxia telangiectasia group D-associated protein) |
| Protein Family |
N/A |
| NCBI Gene ID |
23650
|
| UniProt ID |
Q14134
|
| Enzyme Class |
- |
| Molecular Weight |
65835 |
| Protein Length |
588 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Cytoplasm Note=Colocalizes with intermediate filaments. |
| Function (UniProt annotation) |
Plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract. Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its 'Lys-48' ubiquitination and subsequent degradation. In turn, the expression of type I interferons and the production of proinflammatory cytokines are inhibited. Additionally, induces the 'Lys-48' ubiquitination of TMEM173/STING in a similar way, leading to its degradation. |
| Gene Ontology |
GO:0000122; GO:0002039; GO:0003700; GO:0005764; GO:0005913; GO:0006366; GO:0008270; GO:0042802; GO:0045087; GO:0098641; GO:1900181 |
