CaMKinet | Result

Graphics credits: COMPARTMENTS | More Info

Sequence Viewer

Parameter	Value
Gene	MELK
Protein Name	MELK_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	Maternal embryonic leucine zipper kinase (hMELK) (EC 2.7.11.1) (Protein kinase Eg3) (pEg3 kinase) (Protein kinase PK38) (hPK38) (Tyrosine-protein kinase MELK) (EC 2.7.10.2)
Protein Family	Protein kinase superfamily
NCBI Gene ID	9833
UniProt ID	Q14680
Enzyme Class	2.7.11.1; 2.7.10.2
Molecular Weight	74642
Protein Length	651
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
Localization	Cell membrane
Function (UniProt annotation)	Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. Plays a key role in cell proliferation and carcinogenesis. Required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14, possibly leading to affect mammary carcinogenesis by mediating inhibition of the pro-apoptotic function of BCL2L14. Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus. May also play a role in primitive hematopoiesis.
Gene Ontology	GO:0000086; GO:0004674; GO:0004715; GO:0005509; GO:0005524; GO:0005634; GO:0005737; GO:0005886; GO:0005938; GO:0006468; GO:0006915; GO:0008283; GO:0008289; GO:0008631; GO:0016020; GO:0030097; GO:0035556; GO:0043065; GO:0046777; GO:0061351

Gene Ontology

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
MELK (Q14680)	Homo sapiens	S505	SPERRCRSVELDLNQ	0.99	0.4831	TP	certain	experimental	214 \| 73 \|	16216881	-	In vitro and in vivo
MELK (Q14680)	Homo sapiens	S529	KGAKVFGSLERGLDK	0.947	0.4256	TP	certain	experimental	214 \| 73 \|	16216881	-	In vitro and in vivo
MELK (Q14680)	Homo sapiens	S253	VDPKKRISMKNLLNH	0.09	0.1323	TP	certain	experimental	214 \| 73 \|	16216881	-	In vitro
MELK (Q14680)	Homo sapiens	S336	PVRLRLSSFSCGQAS	0.226	0.3704	TP	certain	experimental	214 \| 73 \|	16216881	-	In vitro
MELK (Q14680)	Homo sapiens	S343	SFSCGQASATPFTDI	0.353	0.3087	TP	certain	experimental	214 \| 73 \|	16216881	-	In vitro and in vivo
MELK (Q14680)	Homo sapiens	S356	DIKSNNWSLEDVTAS	0.482	0.422	TP	certain	experimental	214 \| 73 \|	16216881	-	In vitro and in vivo
MELK (Q14680)	Homo sapiens	S391	GAATPRTSQFTKYWT	0.199	0.4541	TP	certain	experimental	214 \| 73 \|	16216881	-	In vitro
MELK (Q14680)	Homo sapiens	S407	SNGVESKSLTPALCR	0.414	0.4476	TP	certain	experimental	214 \| 73 \|	16216881	-	In vitro
MELK (Q14680)	Homo sapiens	S431	ENVYTPKSAVKNEEY	0.292	0.4087	TP	certain	experimental	214 \| 73 \|	16216881	-	In vitro and in vivo
STK11 (Q15831)	Homo sapiens	T167	NKDYHLQTCCGSLAY	0.843	0.1476	TP	certain	experimental	214 \| 8 \|	14976552	Non high throughput (14976552)	In vitro
MELK (Q14680)	Homo sapiens	T398	SQFTKYWTESNGVES	0.412	0.4507	TP	certain	experimental	214 \| 73 \|	16216881	-	In vitro and in vivo
MELK (Q14680)	Homo sapiens	T409	GVESKSLTPALCRTP	0.926	0.5577	TP	certain	experimental	214 \| 72 \|	16628004	-	In vivo
MELK (Q14680)	Homo sapiens	T494	TGTDKLMTGVISPER	0.292	0.5577	TP	certain	experimental	214 \| 73 \|	16216881	-	In vitro and in vivo
MELK (Q14680)	Homo sapiens	T539	RGLDKVITVLTRSKR	0.299	0.4507	TP	certain	experimental	214 \| 73 \|	16216881	-	In vitro
MELK (Q14680)	Homo sapiens	T56	SDLPRIKTEIEALKN	0.221	0.2328	TP	certain	experimental	214 \| 73 \|	16216881	-	In vitro
MELK (Q14680)	Homo sapiens	S171	HLQTCCGSLAYAAPE	0.822	0.0463	TP	certain	experimental	62 \| 30 \|	16216881	-	-
MELK (Q14680)	Homo sapiens	T167	NKDYHLQTCCGSLAY	0.843	0.1476	TP	certain	experimental	62 \| 30 \|	16216881	-	-
MELK (Q14680)	Homo sapiens	S405	TESNGVESKSLTPAL	0.693	0.3631	-	-	-	-	-	-	In vivo
MELK (Q14680)	Homo sapiens	T387	DLSTGAATPRTSQFT	0.181	0.3599	-	-	-	-	-	-	In vivo

Interaction Network

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

No KEGG pathways found

No NCI Nature pathways found