| Gene |
CASP8
|
| Protein Name |
CASP8_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Caspase-8 (CASP-8) (EC 3.4.22.61) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) (FADD-homologous ICE/ced-3-like protease) (FADD-like ICE) (FLICE) (ICE-like apoptotic protease 5) (MORT1-associated ced-3 homolog) (MACH) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10] |
| Protein Family |
Peptidase C14A family |
| NCBI Gene ID |
841
|
| UniProt ID |
Q14790
|
| Enzyme Class |
3.4.22.61 |
| Molecular Weight |
55391 |
| Protein Length |
479 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
Strict requirement for Asp at position P1 and has a preferred cleavage sequence of (Leu/Asp/Val)-Glu-Thr-Asp-|-(Gly/Ser/Ala). |
| Localization |
Cytoplasm. |
| Function (UniProt annotation) |
Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Cleaves and activates CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10. May participate in the GZMB apoptotic pathways. Cleaves ADPRT. Hydrolyzes the small-molecule substrate, Ac-Asp-Glu-Val-Asp-|-AMC. Likely target for the cowpox virus CRMA death inhibitory protein. Isoform 5, isoform 6, isoform 7 and isoform 8 lack the catalytic site and may interfere with the pro-apoptotic activity of the complex. |
| Gene Ontology |
GO:0004197; GO:0005123; GO:0005164; GO:0005654; GO:0005737; GO:0005739; GO:0005741; GO:0005829; GO:0005856; GO:0006508; GO:0006915; GO:0006919; GO:0007166; GO:0008233; GO:0008234; GO:0008625; GO:0009409; GO:0010803; GO:0030101; GO:0030225; GO:0031264; GO:0031265; GO:0031625; GO:0032025; GO:0032355; GO:0032496; GO:0034138; GO:0034612; GO:0035666; GO:0035877; GO:0036462; GO:0039650; GO:0042110; GO:0042113; GO:0042802; GO:0043005; GO:0043123; GO:0043124; GO:0044297; GO:0044877; GO:0045121; GO:0045471; GO:0045651; GO:0045862; GO:0051603; GO:0060544; GO:0060715; GO:0070423; GO:0071260; GO:0071407; GO:0071550; GO:0097110; GO:0097153; GO:0097190; GO:0097191; GO:0097194; GO:0097199; GO:0097202; GO:0097296; GO:0097342; GO:1900740; GO:1901216; GO:1902041; GO:1902042 |
