| Gene |
SNX17
|
| Protein Name |
SNX17_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Sorting nexin-17 |
| Protein Family |
Sorting nexin family |
| NCBI Gene ID |
9784
|
| UniProt ID |
Q15036
|
| Enzyme Class |
- |
| Molecular Weight |
52901 |
| Protein Length |
470 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Cytoplasm. Early endosome. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. |
| Function (UniProt annotation) |
Critical regulator of endosomal recycling of numerous receptors, channels, and other transmembrane proteins. Binds to NPxY sequences in the cytoplasmic tails of target cargos. Plays a role in the sorting of endocytosed LRP1 and APP, and prevents their degradation. Required for maintenance of normal cell surface levels of APP and LRP1. Recycles internalized integrins ITGB1, ITGB5 and their associated alpha subunits, preventing them from lysosomal degradation. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)). |
| Gene Ontology |
GO:0003279; GO:0005102; GO:0005768; GO:0005769; GO:0005794; GO:0005829; GO:0006707; GO:0006886; GO:0006898; GO:0007165; GO:0008022; GO:0010008; GO:0016020; GO:0016197; GO:0030100; GO:0030659; GO:0031410; GO:0032991; GO:0035091; GO:0035904; GO:0043231; GO:0050750; GO:0060976; GO:1990126 |
