CaMKinet | Result

Sequence Viewer

Parameter	Value
Gene	RHEB
Protein Name	RHEB_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	GTP-binding protein Rheb (Ras homolog enriched in brain)
Protein Family	Small GTPase superfamily
NCBI Gene ID	6009
UniProt ID	Q15382
Enzyme Class	-
Molecular Weight	20497
Protein Length	184
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	-
Localization	Endomembrane system
Function (UniProt annotation)	Activates the protein kinase activity of mTORC1, and thereby plays a role in the regulation of apoptosis. Stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling. Has low intrinsic GTPase activity.
Gene Ontology	GO:0000139; GO:0000287; GO:0003924; GO:0005525; GO:0005681; GO:0005765; GO:0005789; GO:0005829; GO:0007050; GO:0007165; GO:0014069; GO:0016020; GO:0016241; GO:0019003; GO:0019901; GO:0032008; GO:0048714; GO:0070062; GO:0120163; GO:2000074

Gene Ontology

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
MAPKAPK5 (Q8IW41)	Homo sapiens	S130	LHMERVISYEEGKAL	0.505	0.2783	-	-	-	-	-	-	in-vivo

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

No KEGG pathways found

No NCI Nature pathways found