CaMKinet | Result

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Sequence Viewer

Parameter	Value
Gene	STK11
Protein Name	STK11_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	Serine/threonine-protein kinase STK11 (EC 2.7.11.1) (Liver kinase B1) (LKB1) (hLKB1) (Renal carcinoma antigen NY-REN-19)
Protein Family	Protein kinase superfamily
NCBI Gene ID	6794
UniProt ID	Q15831
Enzyme Class	2.7.11.1
Molecular Weight	48636
Protein Length	433
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	ATP + a protein = ADP + a phosphoprotein.
Localization	Nucleus. Cytoplasm. Membrane Note=Predominantly nuclear, but translocates to the cytoplasm in response to metformin or peroxynitrite treatment.
Function (UniProt annotation)	Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, thus promoting their activity: phosphorylates PRKAA1, PRKAA2, BRSK1, BRSK2, MARK1, MARK2, MARK3, MARK4, NUAK1, NUAK2, SIK1, SIK2, SIK3 and SNRK but not MELK. Also phosphorylates non-AMPK family proteins such as STRADA, PTEN and possibly p53/TP53. Acts as a key upstream regulator of AMPK by mediating phosphorylation and activation of AMPK catalytic subunits PRKAA1 and PRKAA2 and thereby regulates processes including: inhibition of signaling pathways that promote cell growth and proliferation when energy levels are low, glucose homeostasis in liver, activation of autophagy when cells undergo nutrient deprivation, and B-cell differentiation in the germinal center in response to DNA damage. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton. Required for cortical neuron polarization by mediating phosphorylation and activation of BRSK1 and BRSK2, leading to axon initiation and specification. Involved in DNA damage response: interacts with p53/TP53 and recruited to the CDKN1A/WAF1 promoter to participate in transcription activation. Able to phosphorylate p53/TP53; the relevance of such result in vivo is however unclear and phosphorylation may be indirect and mediated by downstream STK11/LKB1 kinase NUAK1. Also acts as a mediator of p53/TP53-dependent apoptosis via interaction with p53/TP53: translocates to the mitochondrion during apoptosis and regulates p53/TP53-dependent apoptosis pathways. In vein endothelial cells, inhibits PI3K/Akt signaling activity and thus induces apoptosis in response to the oxidant peroxynitrite (in vitro). Regulates UV radiation-induced DNA damage response mediated by CDKN1A. In association with NUAK1, phosphorylates CDKN1A in response to UV radiation and contributes to its degradation which is necessary for optimal DNA repair (PubMed:25329316).
Gene Ontology	GO:0000287; GO:0001558; GO:0001894; GO:0001944; GO:0002039; GO:0004674; GO:0005524; GO:0005634; GO:0005654; GO:0005737; GO:0005739; GO:0005829; GO:0006468; GO:0006470; GO:0006914; GO:0006974; GO:0007050; GO:0007283; GO:0007409; GO:0008285; GO:0010212; GO:0010508; GO:0016020; GO:0030010; GO:0030275; GO:0030295; GO:0030308; GO:0030511; GO:0032147; GO:0042593; GO:0043276; GO:0045059; GO:0046777; GO:0048814; GO:0050772; GO:0050852; GO:0051645; GO:0051896; GO:0060070; GO:0060770; GO:0070062; GO:0071493; GO:0072332; GO:0090090; GO:0097484; GO:0120163; GO:1900182; GO:1901796; GO:1904262

Gene Ontology

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
STK11 (Q15831)	Homo sapiens	T189	LLLTTGGTLKISDLG	0.486	0.2193	TP	certain	experimental	73 \| 8 \|	11430832	Non high throughput (11430832)	In vitro
STK11 (Q15831)	Homo sapiens	T185	KPGNLLLTTGGTLKI	0.389	0.2193	TP	certain	experimental	30 \| 72 \| 133 \| 135 \|	12805220	-	-
STK11 (Q15831)	Homo sapiens	T402	TEAAQLSTKSRAEGR	0.175	0.8279	TP	certain	experimental	30 \| 72 \| 133 \| 135 \|	12805220	-	-
STK11 (Q15831)	Homo sapiens	T336	KDRWRSMTVVPYLED	0.974	0.4619	TP	certain	experimental	72 \| 55 \| 30 \| 133 \| 135 \|	12805220	-	-
STK11 (Q15831)	Homo sapiens	T363	IEDDIIYTQDFTVPG	0.391	0.3529	TP	certain	experimental	72 \| 55 \| 30 \| 133 \| 135 \|	12805220	-	-
STK11 (Q15831)	Homo sapiens	S428	SSKIRRLSACKQQ__	0.975	0.384	-	-	-	-	-	-	In vitro

Interaction Network

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

KEGG Pathways

Pathway ID	Pathway Name
hsa04150	mTOR signaling pathway
hsa04920	Adipocytokine signaling pathway

No NCI Nature pathways found