CaMKinet | Result

Sequence Viewer

Parameter	Value
Gene	PFKFB3
Protein Name	F263_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (6PF-2-K/Fru-2,6-P2ase 3) (PFK/FBPase 3) (6PF-2-K/Fru-2,6-P2ase brain/placenta-type isozyme) (Renal carcinoma antigen NY-REN-56) (iPFK-2) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)]
Protein Family	Phosphoglycerate mutase family
NCBI Gene ID	5209
UniProt ID	Q16875
Enzyme Class	2.7.1.105; 3.1.3.46
Molecular Weight	59609
Protein Length	520
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	Beta-D-fructose 2
Localization	N/A
Function (UniProt annotation)	Synthesis and degradation of fructose 2,6-bisphosphate.
Gene Ontology	GO:0003873; GO:0004331; GO:0005524; GO:0005654; GO:0005829; GO:0006000; GO:0006003; GO:0007420; GO:0045821

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
PRKAA1 (Q13131)	Homo sapiens	S461	NPLMRRNSVTPLASP	0.121	0.7672	TP	certain	experimental	73 \| 55 \|	12065600	-	In vitro and in vivo
MAPKAPK2 (P49137)	Homo sapiens	S461	NPLMRRNSVTPLASP	0.121	0.7672	-	-	-	-	-	-	in-vivo

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

KEGG Pathways

Pathway ID	Pathway Name
hsa00051	Fructose and mannose metabolism

NCI Nature PID Pathways

Pathway ID	Pathway Name
hif1_tfpathway	HIF-1-alpha transcription factor network