| Gene |
PDCD4
|
| Protein Name |
PDCD4_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Programmed cell death protein 4 (Neoplastic transformation inhibitor protein) (Nuclear antigen H731-like) (Protein 197/15a) |
| Protein Family |
PDCD4 family |
| NCBI Gene ID |
27250
|
| UniProt ID |
Q53EL6
|
| Enzyme Class |
- |
| Molecular Weight |
51735 |
| Protein Length |
469 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Nucleus |
| Function (UniProt annotation) |
Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity). |
| Gene Ontology |
GO:0003723; GO:0005634; GO:0005737; GO:0005829; GO:0006915; GO:0007569; GO:0030509; GO:0035722; GO:0043066; GO:0043508; GO:0045786; GO:0045892; GO:0050729; GO:0060940; GO:0071222; GO:1900016; GO:1901224; GO:1904706; GO:1904761; GO:1905064; GO:1905461; GO:2000353 |
