| Gene |
Sqstm1
|
| Protein Name |
SQSTM_MOUSE |
| Organism |
Mus musculus (Mouse) |
| Alternative name(s) |
Sequestosome-1 (STONE14) (Ubiquitin-binding protein p62) |
| Protein Family |
N/A |
| NCBI Gene ID |
18412
|
| UniProt ID |
Q64337
|
| Enzyme Class |
- |
| Molecular Weight |
48163 |
| Protein Length |
442 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Cytoplasm, cytosol |
| Function (UniProt annotation) |
Autophagy receptor required for selective macroautophagy (aggrephagy). Functions as a bridge between polyubiquitinated cargo and autophagosomes. Interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family. Required both for the formation and autophagic degradation of polyubiquitin-containing bodies, called ALIS (aggresome-like induced structures) and links ALIS to the autophagic machinery. Involved in midbody ring degradation (By similarity). May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. Adapter that mediates the interaction between TRAF6 and CYLD (PubMed:14960283, PubMed:18382763). May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels. Involved in endosome organization by retaining vesicles in the perinuclear cloud: following ubiquitination by RNF26, attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport (By similarity). |
| Gene Ontology |
GO:0000122; GO:0000407; GO:0000423; GO:0000932; GO:0001934; GO:0002376; GO:0002931; GO:0003712; GO:0005080; GO:0005737; GO:0005739; GO:0005770; GO:0005776; GO:0005783; GO:0005829; GO:0006914; GO:0006915; GO:0007005; GO:0007032; GO:0008270; GO:0016234; GO:0016235; GO:0016236; GO:0016605; GO:0019899; GO:0019901; GO:0030017; GO:0030154; GO:0031625; GO:0035255; GO:0035973; GO:0042169; GO:0042802; GO:0042803; GO:0043122; GO:0043130; GO:0043231; GO:0044130; GO:0044753; GO:0044754; GO:0051291; GO:0061635; GO:0061912; GO:0070530; GO:0097225; GO:0097413; GO:0098780; GO:1900273; GO:1903078; GO:1905719 |
