CaMKinet | Result

Sequence Viewer

Parameter	Value
Gene	Kcnk18
Protein Name	KCNKI_MOUSE
Organism	Mus musculus (Mouse)
Alternative name(s)	Potassium channel subfamily K member 18 (Two-pore-domain potassium channel TRESK)
Protein Family	Two pore domain potassium channel (TC 1.A.1.8) family
NCBI Gene ID	332396
UniProt ID	Q6VV64
Enzyme Class	-
Molecular Weight	44403
Protein Length	394
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	-
Localization	Cell membrane
Function (UniProt annotation)	Outward rectifying potassium channel. Produces rapidly activating outward rectifier K(+) currents. May function as background potassium channel that sets the resting membrane potential. Channel activity is directly activated by calcium signal. Activated by the G(q)-protein coupled receptor pathway. The calcium signal robustly activates the channel via calcineurin, whereas the anchoring of 14-3-3/YWHAH interferes with the return of the current to the resting state after activation. Inhibited also by arachidonic acid and other naturally occurring unsaturated free fatty acids. Channel activity is also enhanced by volatile anesthetics, such as isoflurane. Appears to be the primary target of hydroxy-alpha-sanshool, an ingredient of Schezuan pepper. May be involved in the somatosensory function with special respect to pain sensation.
Gene Ontology	GO:0005886; GO:0005887; GO:0006813; GO:0015269; GO:0015271; GO:0022841; GO:0071435; GO:0071467; GO:0071805

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
Mark2 (Q05512)	Mus musculus	S274	ELVLGRLSCSILSNL	N/A	0.0244	TP	certain	experimental	72 \| 9 \|	22145024	-	-
Mark2 (Q05512)	Mus musculus	S276	VLGRLSCSILSNLDE	N/A	0.0494	TP	certain	experimental	72 \| 9 \|	22145024	-	-
Mark2* (Q05512)	Mus musculus	S279	RLSCSILSNLDEVGQ	N/A	0.0494	TP	certain	experimental	72 \| 9 \|	22145024	-	-
MARK2 (Q7KZI7)	Homo sapiens	S279	RLSCSILSNLDEVGQ	N/A	0.0494	-	-	-	-	-	-	in-vitro
MARK2 (Q7KZI7)	Homo sapiens	S274	ELVLGRLSCSILSNL	N/A	0.0244	-	-	-	-	-	-	in-vitro
MARK2 (Q7KZI7)	Homo sapiens	S276	VLGRLSCSILSNLDE	N/A	0.0494	-	-	-	-	-	-	in-vitro

Interaction Network

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

No KEGG pathways found

No NCI Nature pathways found