| Gene |
LPCAT2
|
| Protein Name |
PCAT2_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Lysophosphatidylcholine acyltransferase 2 (LPC acyltransferase 2) (LPCAT-2) (LysoPC acyltransferase 2) (EC 2.3.1.23) (1-acylglycerol-3-phosphate O-acyltransferase 11) (1-AGP acyltransferase 11) (1-AGPAT 11) (EC 2.3.1.51) (1-acylglycerophosphocholine O-acyltransferase) (1-alkylglycerophosphocholine O-acetyltransferase) (EC 2.3.1.67) (Acetyl-CoA:lyso-platelet-activating factor acetyltransferase) (Acetyl-CoA:lyso-PAF acetyltransferase) (Lyso-PAF acetyltransferase) (LysoPAFAT) (Acyltransferase-like 1) (Lysophosphatidic acid acyltransferase alpha) (LPAAT-alpha) |
| Protein Family |
1-acyl-sn-glycerol-3-phosphate acyltransferase family |
| NCBI Gene ID |
54947
|
| UniProt ID |
Q7L5N7
|
| Enzyme Class |
2.3.1.23; 2.3.1.51; 2.3.1.67 |
| Molecular Weight |
60208 |
| Protein Length |
544 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
Acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine = CoA + 1 |
| Localization |
Endoplasmic reticulum membrane |
| Function (UniProt annotation) |
Possesses both acyltransferase and acetyltransferase activities. Activity is calcium-dependent. Involved in platelet-activating factor (PAF) biosynthesis by catalyzing the conversion of the PAF precursor, 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) into 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF). Also converts lyso-PAF to 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine (PC), a major component of cell membranes and a PAF precursor. Under resting conditions, acyltransferase activity is preferred. Upon acute inflammatory stimulus, acetyltransferase activity is enhanced and PAF synthesis increases. Also catalyzes the conversion of 1-acyl-sn-glycero-3-phosphocholine to 1,2-diacyl-sn-glycero-3-phosphocholine. |
| Gene Ontology |
GO:0000139; GO:0003841; GO:0005509; GO:0005783; GO:0005789; GO:0005795; GO:0005811; GO:0006663; GO:0016021; GO:0036151; GO:0047144; GO:0047184; GO:0047192; GO:0061024 |
