| Gene |
ATG9A
|
| Protein Name |
ATG9A_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Autophagy-related protein 9A (APG9-like 1) (mATG9) |
| Protein Family |
ATG9 family |
| NCBI Gene ID |
79065
|
| UniProt ID |
Q7Z3C6
|
| Enzyme Class |
- |
| Molecular Weight |
94447 |
| Protein Length |
839 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Cytoplasmic vesicle, autophagosome membrane; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Under amino acid starvation or rapamycin treatment, redistributes from a juxtanuclear clustered pool to a dispersed peripheral cytosolic pool. The starvation-induced redistribution depends on ULK1, ATG13, as well as SH3GLB1. |
| Function (UniProt annotation) |
Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Cycles between a juxta-nuclear trans-Golgi network compartment and late endosomes. Nutrient starvation induces accumulation on autophagosomes. Starvation-dependent trafficking requires ULK1, ATG13 and SUPT20H. |
| Gene Ontology |
GO:0000045; GO:0000407; GO:0000422; GO:0005768; GO:0005770; GO:0005776; GO:0005789; GO:0005802; GO:0015031; GO:0016020; GO:0016021; GO:0031902; GO:0034497; GO:0043231; GO:0044805; GO:0055037 |
