| Gene |
KCNK18
|
| Protein Name |
KCNKI_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Potassium channel subfamily K member 18 (TWIK-related individual potassium channel) (TWIK-related spinal cord potassium channel) |
| Protein Family |
Two pore domain potassium channel (TC 1.A.1.8) family |
| NCBI Gene ID |
338567
|
| UniProt ID |
Q7Z418
|
| Enzyme Class |
- |
| Molecular Weight |
43671 |
| Protein Length |
384 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Cell membrane |
| Function (UniProt annotation) |
Outward rectifying potassium channel. Produces rapidly activating outward rectifier K(+) currents. May function as background potassium channel that sets the resting membrane potential. Channel activity is directly activated by calcium signal. Activated by the G(q)-protein coupled receptor pathway. The calcium signal robustly activates the channel via calcineurin, whereas the anchoring of 14-3-3/YWHAH interferes with the return of the current to the resting state after activation. Inhibited also by arachidonic acid and other naturally occurring unsaturated free fatty acids. Channel activity is also enhanced by volatile anesthetics, such as isoflurane. Appears to be the primary target of hydroxy-alpha-sanshool, an ingredient of Schezuan pepper. May be involved in the somatosensory function with special respect to pain sensation (By similarity). |
| Gene Ontology |
GO:0005267; GO:0005886; GO:0005887; GO:0006813; GO:0015269; GO:0015271; GO:0022841; GO:0071435; GO:0071467; GO:0071805 |
