CaMKinet | Result

Sequence Viewer

Parameter	Value
Gene	NET1
Protein Name	ARHG8_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	Neuroepithelial cell-transforming gene 1 protein (Proto-oncogene p65 Net1) (Rho guanine nucleotide exchange factor 8)
Protein Family	N/A
NCBI Gene ID	10276
UniProt ID	Q7Z628
Enzyme Class	-
Molecular Weight	67740
Protein Length	596
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	-
Localization	Cytoplasm
Function (UniProt annotation)	Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase. May be involved in activation of the SAPK/JNK pathway Stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death.
Gene Ontology	GO:0001558; GO:0005085; GO:0005089; GO:0005634; GO:0005829; GO:0007165; GO:0007186; GO:0035023; GO:0035556; GO:0043065; GO:0043547; GO:0051056; GO:0051451; GO:0070301; GO:0071479

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
PRKAA1 (Q13131)	Homo sapiens	S100	RPLARVTSLANLISP	0.976	0.4619	-	-	-	-	-	-	in-vivo

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

No KEGG pathways found

No NCI Nature pathways found