| Gene |
Pnpla2
|
| Protein Name |
PLPL2_MOUSE |
| Organism |
Mus musculus (Mouse) |
| Alternative name(s) |
Patatin-like phospholipase domain-containing protein 2 (EC 3.1.1.3) (Adipose triglyceride lipase) (Desnutrin) |
| Protein Family |
N/A |
| NCBI Gene ID |
66853
|
| UniProt ID |
Q8BJ56
|
| Enzyme Class |
3.1.1.3 |
| Molecular Weight |
53657 |
| Protein Length |
486 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
Triacylglycerol + H(2)O = diacylglycerol + a carboxylate. |
| Localization |
Lipid droplet. Cell membrane; Single-pass type II membrane protein. |
| Function (UniProt annotation) |
Catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets (PubMed:15550674). Also has acylglycerol transacylase activity. May act coordinately with LIPE/HLS within the lipolytic cascade. Regulates adiposome size and may be involved in the degradation of adiposomes. May play an important role in energy homeostasis. May play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion. |
| Gene Ontology |
GO:0004806; GO:0005654; GO:0005737; GO:0005811; GO:0005829; GO:0005886; GO:0010891; GO:0010898; GO:0016020; GO:0016021; GO:0019433; GO:0019915; GO:0034389; GO:0044242; GO:0055088 |
