| Gene |
WWC1
|
| Protein Name |
KIBRA_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Protein KIBRA (HBeAg-binding protein 3) (Kidney and brain protein) (KIBRA) (WW domain-containing protein 1) |
| Protein Family |
WWC family |
| NCBI Gene ID |
23286
|
| UniProt ID |
Q8IX03
|
| Enzyme Class |
- |
| Molecular Weight |
125301 |
| Protein Length |
1113 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Cell projection, ruffle membrane. Note=Colocalizes with PRKCZ in the perinuclear region. |
| Function (UniProt annotation) |
Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with NF2 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. Acts as a transcriptional coactivator of ESR1 which plays an essential role in DYNLL1-mediated ESR1 transactivation. Regulates collagen-stimulated activation of the ERK/MAPK cascade. Modulates directional migration of podocytes. Acts as a substrate for PRKCZ. Plays a role in cognition and memory performance. |
| Gene Ontology |
GO:0000122; GO:0003713; GO:0005634; GO:0005737; GO:0005829; GO:0007221; GO:0016477; GO:0019900; GO:0030010; GO:0032386; GO:0032587; GO:0032947; GO:0032991; GO:0035329; GO:0035330; GO:0035331; GO:0043410; GO:0046621; GO:0048471 |
