CaMKinet | Result

Sequence Viewer

Parameter	Value
Gene	Mrtfa
Protein Name	MRTFA_MOUSE
Organism	Mus musculus (Mouse)
Alternative name(s)	Myocardin-related transcription factor A (MRTF-A) (Basic SAP coiled-coil transcription activator) (MKL/myocardin-like protein 1) (Megakaryoblastic leukemia 1 protein homolog) (Megakaryocytic acute leukemia protein homolog)
Protein Family	N/A
NCBI Gene ID	223701
UniProt ID	Q8K4J6
Enzyme Class	-
Molecular Weight	102546
Protein Length	964
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	-
Localization	Cytoplasm
Function (UniProt annotation)	Transcription coactivator that associates with the serum response factor (SRF) transcription factor to control expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration (PubMed:12019265, PubMed:12732141, PubMed:17588931, PubMed:19350017, PubMed:24732378). The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics (PubMed:24732378). MRTFA binds G-actin via its RPEL repeats, regulating activity of the MRTFA-SRF complex (PubMed:12732141, PubMed:17588931). Activity is also regulated by filamentous actin (F-actin) in the nucleus (PubMed:23558171, PubMed:25759381).
Gene Ontology	GO:0000976; GO:0001764; GO:0003700; GO:0003713; GO:0003779; GO:0003785; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006357; GO:0010735; GO:0030036; GO:0030900; GO:0031175; GO:0043154; GO:0043522; GO:0045893; GO:0045944; GO:0051145; GO:2001234

Gene Ontology

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
MAPKAPK2 (P49137)	Homo sapiens	S371	SGLARQSSTALAAKP	N/A	0.6712	-	-	-	-	-	-	in-vivo
MAPKAPK2 (P49137)	Homo sapiens	S351	PTPSRSLSTSSSPSS	N/A	0.923	-	-	-	-	-	-	in-vivo

Interaction Network

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

No KEGG pathways found

No NCI Nature pathways found