| Gene |
TAB3
|
| Protein Name |
TAB3_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 3) (NF-kappa-B-activating protein 1) (TAK1-binding protein 3) (TAB-3) (TGF-beta-activated kinase 1-binding protein 3) |
| Protein Family |
N/A |
| NCBI Gene ID |
257397
|
| UniProt ID |
Q8N5C8
|
| Enzyme Class |
- |
| Molecular Weight |
78653 |
| Protein Length |
712 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
N/A |
| Function (UniProt annotation) |
Adapter linking MAP3K7/TAK1 and TRAF6 or TRAF2. Mediator of MAP3K7 activation, respectively in the IL1 and TNF signaling pathways. Plays a role in activation of NF-kappa-B and AP1 transcription factor. Isoform 2 may be an oncogenic factor. |
| Gene Ontology |
GO:0000187; GO:0002223; GO:0002755; GO:0005829; GO:0005886; GO:0007249; GO:0007254; GO:0010008; GO:0010507; GO:0038095; GO:0046872; GO:0051092; GO:0070062; GO:0070423; GO:0070498 |
