CaMKinet | Result

Sequence Viewer

Parameter	Value
Gene	DEPTOR
Protein Name	DPTOR_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	DEP domain-containing mTOR-interacting protein (DEP domain-containing protein 6)
Protein Family	N/A
NCBI Gene ID	64798
UniProt ID	Q8TB45
Enzyme Class	-
Molecular Weight	46294
Protein Length	409
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	-
Localization	N/A
Function (UniProt annotation)	Negative regulator of the mTORC1 and mTORC2 signaling pathways. Inhibits the kinase activity of both complexes.
Gene Ontology	GO:0005622; GO:0006469; GO:0032007; GO:0035556; GO:0045792; GO:2001236

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
RPS6KA1 (Q15418)	Homo sapiens	S286	SSMSSCGSSGYFSSS	0.184	0.346	-	-	-	-	-	-	In vitro and in vivo
RPS6KA1 (Q15418)	Homo sapiens	S287	SMSSCGSSGYFSSSP	0.801	0.3948	-	-	-	-	-	-	In vitro and in vivo
RPS6KA1 (Q15418)	Homo sapiens	S291	CGSSGYFSSSPTLSS	0.165	0.4256	-	-	-	-	-	-	In vitro and in vivo

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

No KEGG pathways found

No NCI Nature pathways found