| Gene |
PARD3
|
| Protein Name |
PARD3_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Partitioning defective 3 homolog (PAR-3) (PARD-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (CTCL tumor antigen se2-5) (PAR3-alpha) |
| Protein Family |
PAR3 family |
| NCBI Gene ID |
56288
|
| UniProt ID |
Q8TEW0
|
| Enzyme Class |
- |
| Molecular Weight |
151423 |
| Protein Length |
1356 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Cytoplasm |
| Function (UniProt annotation) |
Adapter protein involved in asymmetrical cell division and cell polarization processes (PubMed:27925688, PubMed:10954424). Seems to play a central role in the formation of epithelial tight junctions (PubMed:27925688). Targets the phosphatase PTEN to cell junctions (By similarity). Involved in Schwann cell peripheral myelination (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly (By similarity). The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10934474). Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (PubMed:19812038, PubMed:27925688). |
| Gene Ontology |
GO:0000226; GO:0005546; GO:0005547; GO:0005737; GO:0005829; GO:0005856; GO:0005886; GO:0005911; GO:0005912; GO:0005913; GO:0005923; GO:0005938; GO:0006612; GO:0007049; GO:0007155; GO:0007163; GO:0007179; GO:0007205; GO:0007409; GO:0008104; GO:0008356; GO:0010801; GO:0012505; GO:0016324; GO:0019903; GO:0022011; GO:0030010; GO:0030054; GO:0031643; GO:0032266; GO:0032991; GO:0033269; GO:0035091; GO:0042802; GO:0043025; GO:0043296; GO:0044295; GO:0045197; GO:0060341; GO:0065003; GO:0070830; GO:0090162 |
