| Gene |
TTN
|
| Protein Name |
TITIN_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS-40.14) |
| Protein Family |
Protein kinase superfamily |
| NCBI Gene ID |
7273
|
| UniProt ID |
Q8WZ42
|
| Enzyme Class |
2.7.11.1 |
| Molecular Weight |
3816030 |
| Protein Length |
34350 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
ATP + a protein = ADP + a phosphoprotein. |
| Localization |
Cytoplasm |
| Function (UniProt annotation) |
Key component in the assembly and functioning of vertebrate striated muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The size and extensibility of the cross-links are the main determinants of sarcomere extensibility properties of muscle. In non-muscle cells, seems to play a role in chromosome condensation and chromosome segregation during mitosis. Might link the lamina network to chromatin or nuclear actin, or both during interphase. |
| Gene Ontology |
GO:0000794; GO:0002020; GO:0002576; GO:0003300; GO:0004674; GO:0004713; GO:0005509; GO:0005516; GO:0005524; GO:0005576; GO:0005829; GO:0005865; GO:0006936; GO:0006941; GO:0007076; GO:0008307; GO:0010628; GO:0010737; GO:0019899; GO:0019901; GO:0030017; GO:0030018; GO:0030049; GO:0030240; GO:0030241; GO:0031430; GO:0031433; GO:0031674; GO:0035995; GO:0042802; GO:0042805; GO:0043621; GO:0045214; GO:0045859; GO:0048739; GO:0048769; GO:0050714; GO:0050790; GO:0051015; GO:0051371; GO:0051592; GO:0055003; GO:0055008; GO:0060048; GO:0070062; GO:0097493 |
