| Gene |
Med1
|
| Protein Name |
MED1_MOUSE |
| Organism |
Mus musculus (Mouse) |
| Alternative name(s) |
Mediator of RNA polymerase II transcription subunit 1 (Mediator complex subunit 1) (Peroxisome proliferator-activated receptor-binding protein) (PBP) (PPAR-binding protein) (Thyroid hormone receptor-associated protein complex 220 kDa component) (Trap220) (Thyroid receptor-interacting protein 2) (TR-interacting protein 2) (TRIP-2) |
| Protein Family |
Mediator complex subunit 1 family |
| NCBI Gene ID |
19014
|
| UniProt ID |
Q925J9
|
| Enzyme Class |
- |
| Molecular Weight |
167141 |
| Protein Length |
1575 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Nucleus |
| Function (UniProt annotation) |
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Essential for embryogenesis, including development of the central nervous system, heart, liver and placenta and for erythropoiesis. Also required for normal transcriptional control of thyroid-stimulating hormone beta (TSHB) in the pituitary. Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (By similarity). |
| Gene Ontology |
GO:0000122; GO:0000151; GO:0000785; GO:0000902; GO:0000978; GO:0000979; GO:0000981; GO:0001047; GO:0001525; GO:0001701; GO:0001889; GO:0001892; GO:0002088; GO:0002154; GO:0003222; GO:0003406; GO:0003677; GO:0003682; GO:0003712; GO:0003713; GO:0005634; GO:0005654; GO:0005730; GO:0006355; GO:0006356; GO:0006366; GO:0006367; GO:0006590; GO:0006702; GO:0007275; GO:0007420; GO:0007507; GO:0007595; GO:0008134; GO:0008284; GO:0009887; GO:0010628; GO:0010839; GO:0016567; GO:0016592; GO:0016922; GO:0030216; GO:0030224; GO:0030331; GO:0030374; GO:0030375; GO:0030518; GO:0030521; GO:0031100; GO:0031490; GO:0032993; GO:0033148; GO:0033160; GO:0033598; GO:0033601; GO:0035050; GO:0035116; GO:0035162; GO:0035257; GO:0035357; GO:0035729; GO:0035855; GO:0036033; GO:0038023; GO:0042789; GO:0042809; GO:0042974; GO:0042975; GO:0043010; GO:0043066; GO:0044877; GO:0045444; GO:0045618; GO:0045648; GO:0045665; GO:0045893; GO:0045944; GO:0046966; GO:0048821; GO:0048822; GO:0050693; GO:0060335; GO:0060744; GO:0060745; GO:0060750; GO:0061630; GO:0070318; GO:0070371; GO:0070562; GO:0071364; GO:0071383; GO:0097067; GO:2000273; GO:2000347; GO:2001141 |
