| Gene |
ESR2
|
| Protein Name |
ESR2_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Estrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group A member 2) |
| Protein Family |
Nuclear hormone receptor family |
| NCBI Gene ID |
2100
|
| UniProt ID |
Q92731
|
| Enzyme Class |
- |
| Molecular Weight |
59216 |
| Protein Length |
530 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Nucleus |
| Function (UniProt annotation) |
Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner (PubMed:20074560). Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual. |
| Gene Ontology |
GO:0000122; GO:0000978; GO:0000981; GO:0003677; GO:0003700; GO:0003707; GO:0003713; GO:0004879; GO:0005496; GO:0005576; GO:0005634; GO:0005654; GO:0005739; GO:0006355; GO:0006367; GO:0007165; GO:0007267; GO:0008270; GO:0019899; GO:0030284; GO:0030308; GO:0030520; GO:0034056; GO:0038052; GO:0042802; GO:0045893; GO:0045944; GO:0048019; GO:0051091; GO:0071392 |
