| Gene |
MRTFA
|
| Protein Name |
MRTFA_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Myocardin-related transcription factor A (MRTF-A) (MKL/myocardin-like protein 1) (Megakaryoblastic leukemia 1 protein) (Megakaryocytic acute leukemia protein) |
| Protein Family |
N/A |
| NCBI Gene ID |
57591
|
| UniProt ID |
Q969V6
|
| Enzyme Class |
- |
| Molecular Weight |
98919 |
| Protein Length |
931 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Cytoplasm |
| Function (UniProt annotation) |
Transcription coactivator that associates with the serum response factor (SRF) transcription factor to control expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration. The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G-actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. MRTFA binds G-actin via its RPEL repeats, regulating activity of the MRTFA-SRF complex. Activity is also regulated by filamentous actin (F-actin) in the nucleus. |
| Gene Ontology |
GO:0003713; GO:0003779; GO:0003785; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0010735; GO:0030036; GO:0043522; GO:0045944; GO:0051145 |
