| Gene |
WNK4
|
| Protein Name |
WNK4_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase lysine-deficient 4) (Protein kinase with no lysine 4) |
| Protein Family |
Protein kinase superfamily |
| NCBI Gene ID |
65266
|
| UniProt ID |
Q96J92
|
| Enzyme Class |
2.7.11.1 |
| Molecular Weight |
134739 |
| Protein Length |
1243 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
ATP + a protein = ADP + a phosphoprotein. |
| Localization |
Cell junction, tight junction |
| Function (UniProt annotation) |
Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D, SGK1, TRPV5 and TRPV6. Regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation which appears to prevent membrane trafficking of SLC12A3. Also inhibits the renal K(+) channel, KCNJ1, via a kinase-independent mechanism by which it induces clearance of the protein from the cell surface by clathrin-dependent endocytosis. WNK4 appears to act as a molecular switch that can vary the balance between NaCl reabsorption and K(+) secretion to maintain integrated homeostasis. Phosphorylates NEDD4L. Acts as a scaffold to inhibit SLC4A4 as well as CFTR activities and surface expression, recruits STK39 which mediates the inhibition (By similarity). |
| Gene Ontology |
GO:0004674; GO:0005524; GO:0005737; GO:0005829; GO:0005923; GO:0006468; GO:0006811; GO:0006821; GO:0008104; GO:0010766; GO:0016020; GO:0019869; GO:0019870; GO:0032414; GO:0035556; GO:0050794; GO:0050801; GO:0070294; GO:0072156; GO:0090188; GO:1903288; GO:2000651 |
