| Gene |
UHRF1
|
| Protein Name |
UHRF1_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
E3 ubiquitin-protein ligase UHRF1 (EC 2.3.2.27) (Inverted CCAAT box-binding protein of 90 kDa) (Nuclear protein 95) (Nuclear zinc finger protein Np95) (HuNp95) (hNp95) (RING finger protein 106) (RING-type E3 ubiquitin transferase UHRF1) (Transcription factor ICBP90) (Ubiquitin-like PHD and RING finger domain-containing protein 1) (hUHRF1) (Ubiquitin-like-containing PHD and RING finger domains protein 1) |
| Protein Family |
N/A |
| NCBI Gene ID |
29128
|
| UniProt ID |
Q96T88
|
| Enzyme Class |
2.3.2.27 |
| Molecular Weight |
89814 |
| Protein Length |
793 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. |
| Localization |
Nucleus Note=Localizes to replication foci. Enriched in pericentric heterochromatin. Also localizes to euchromatic regions. |
| Function (UniProt annotation) |
Multidomain protein that acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification. Specifically recognizes and binds hemimethylated DNA at replication forks via its YDG domain and recruits DNMT1 methyltransferase to ensure faithful propagation of the DNA methylation patterns through DNA replication. In addition to its role in maintenance of DNA methylation, also plays a key role in chromatin modification: through its tudor-like regions and PHD-type zinc fingers, specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3) and unmethylated at 'Arg-2' (H3R2me0), respectively, and recruits chromatin proteins. Enriched in pericentric heterochromatin where it recruits different chromatin modifiers required for this chromatin replication. Also localizes to euchromatic regions where it negatively regulates transcription possibly by impacting DNA methylation and histone modifications. Has E3 ubiquitin-protein ligase activity by mediating the ubiquitination of target proteins such as histone H3 and PML. It is still unclear how E3 ubiquitin-protein ligase activity is related to its role in chromatin in vivo. May be involved in DNA repair. |
| Gene Ontology |
GO:0000122; GO:0000790; GO:0000791; GO:0000792; GO:0000987; GO:0003700; GO:0004842; GO:0005634; GO:0005657; GO:0005720; GO:0006281; GO:0006511; GO:0007049; GO:0008270; GO:0008283; GO:0008327; GO:0010216; GO:0010390; GO:0016363; GO:0016567; GO:0016574; GO:0031493; GO:0032270; GO:0035064; GO:0042393; GO:0042802; GO:0044729; GO:0045944; GO:0051865; GO:0061630; GO:2000373 |
