| Gene |
PHB2
|
| Protein Name |
PHB2_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Prohibitin-2 (B-cell receptor-associated protein BAP37) (D-prohibitin) (Repressor of estrogen receptor activity) |
| Protein Family |
Prohibitin family |
| NCBI Gene ID |
11331
|
| UniProt ID |
Q99623
|
| Enzyme Class |
- |
| Molecular Weight |
33296 |
| Protein Length |
299 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Mitochondrion inner membrane |
| Function (UniProt annotation) |
Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases (By similarity). Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging. |
| Gene Ontology |
GO:0000060; GO:0005634; GO:0005737; GO:0005739; GO:0005741; GO:0005743; GO:0006851; GO:0007005; GO:0007062; GO:0008022; GO:0009986; GO:0016363; GO:0030331; GO:0031536; GO:0032991; GO:0033147; GO:0033218; GO:0033600; GO:0043066; GO:0043433; GO:0045892; GO:0047485; GO:0050821; GO:0051091; GO:0060744; GO:0060749; GO:0060762; GO:0070374; GO:0071944; GO:1902808 |
