CaMKinet | Result

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Sequence Viewer

Parameter	Value
Gene	NKX3-1
Protein Name	NKX31_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	Homeobox protein Nkx-3.1 (Homeobox protein NK-3 homolog A)
Protein Family	NK-3 homeobox family
NCBI Gene ID	4824
UniProt ID	Q99801
Enzyme Class	-
Molecular Weight	26350
Protein Length	234
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	-
Localization	Nucleus
Function (UniProt annotation)	Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells.
Gene Ontology	GO:0000976; GO:0000978; GO:0000981; GO:0000983; GO:0001656; GO:0001756; GO:0001934; GO:0003700; GO:0004882; GO:0005622; GO:0005634; GO:0006355; GO:0006919; GO:0007275; GO:0007431; GO:0007507; GO:0008134; GO:0008284; GO:0008285; GO:0008584; GO:0010628; GO:0010629; GO:0010942; GO:0014068; GO:0030284; GO:0030295; GO:0030331; GO:0030521; GO:0033574; GO:0035690; GO:0035907; GO:0042826; GO:0043280; GO:0043491; GO:0043565; GO:0043569; GO:0043621; GO:0044212; GO:0045892; GO:0045893; GO:0045930; GO:0045931; GO:0045944; GO:0048754; GO:0050680; GO:0051781; GO:0060037; GO:0060442; GO:0060664; GO:0060770; GO:0071347; GO:0071356; GO:0071383; GO:0071456; GO:0071850; GO:0071899; GO:0097162; GO:2000836; GO:2001022; GO:2001235; GO:2001244

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
PIM1 (P11309)	Homo sapiens	S195	LGDLEKHSSLPALKE	0.244	0.3807	-	-	-	-	-	-	in-vitro
PIM1 (P11309)	Homo sapiens	S186	TKRKQLSSELGDLEK	0.27	0.5098	-	-	-	-	-	-	in-vitro
PIM1 (P11309)	Homo sapiens	S196	GDLEKHSSLPALKEE	0.106	0.3774	-	-	-	-	-	-	in-vitro
PIM1 (P11309)	Homo sapiens	S185	KTKRKQLSSELGDLE	0.098	0.5176	-	-	-	-	-	-	in-vitro
PIM1 (P11309)	Homo sapiens	T89	AAPEEAETLAETEPE	0.416	0.9081	-	-	-	-	-	-	in-vitro

Interaction Network

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

No KEGG pathways found

No NCI Nature pathways found