| Gene |
TINF2
|
| Protein Name |
TINF2_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
TERF1-interacting nuclear factor 2 (TRF1-interacting nuclear protein 2) |
| Protein Family |
N/A |
| NCBI Gene ID |
26277
|
| UniProt ID |
Q9BSI4
|
| Enzyme Class |
- |
| Molecular Weight |
50023 |
| Protein Length |
451 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Nucleus |
| Function (UniProt annotation) |
Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Plays a role in shelterin complex assembly. Isoform 1 may have additional role in tethering telomeres to the nuclear matrix. |
| Gene Ontology |
GO:0000781; GO:0000783; GO:0000784; GO:0005654; GO:0010370; GO:0010836; GO:0016233; GO:0016363; GO:0016604; GO:0032202; GO:0032211; GO:0042162; GO:0050680; GO:0070187; GO:0070198; GO:1904356 |
