| Gene |
MKNK1
|
| Protein Name |
MKNK1_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (MAPK signal-integrating kinase 1) (Mnk1) |
| Protein Family |
Protein kinase superfamily |
| NCBI Gene ID |
8569
|
| UniProt ID |
Q9BUB5
|
| Enzyme Class |
2.7.11.1 |
| Molecular Weight |
51342 |
| Protein Length |
465 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
ATP + a protein = ADP + a phosphoprotein. |
| Localization |
Isoform 2: Cytoplasm.; Isoform 3: Cytoplasm. Nucleus. |
| Function (UniProt annotation) |
May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. |
| Gene Ontology |
GO:0004674; GO:0004683; GO:0005524; GO:0005634; GO:0005654; GO:0005737; GO:0005829; GO:0006417; GO:0006468; GO:0009931; GO:0018105; GO:0035556; GO:0046872 |
