CaMKinet | Result

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Sequence Viewer

Parameter	Value
Gene	PINK1
Protein Name	PINK1_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	Serine/threonine-protein kinase PINK1, mitochondrial (EC 2.7.11.1) (BRPK) (PTEN-induced putative kinase protein 1)
Protein Family	Protein kinase superfamily
NCBI Gene ID	65018
UniProt ID	Q9BXM7
Enzyme Class	2.7.11.1
Molecular Weight	62769
Protein Length	581
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	ATP + a protein = ADP + a phosphoprotein.
Localization	Mitochondrion outer membrane
Function (UniProt annotation)	Protects against mitochondrial dysfunction during cellular stress by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) by mediating activation and translocation of PRKN (PubMed:14607334, PubMed:15087508, PubMed:19229105, PubMed:19966284, PubMed:20404107, PubMed:20798600, PubMed:23620051, PubMed:23754282, PubMed:23933751, PubMed:24660806, PubMed:24751536, PubMed:24784582, PubMed:24896179, PubMed:25527291). Targets PRKN to dysfunctional depolarized mitochondria through the phosphorylation of MFN2 (PubMed:23620051). Activates PRKN in 2 steps: (1) by mediating phosphorylation at 'Ser-65' of PRKN and (2) mediating phosphorylation of ubiquitin, converting PRKN to its fully-active form (PubMed:24660806, PubMed:24751536, PubMed:24784582, PubMed:25527291). Required for ubiquinone reduction by mitochondrial complex I by mediating phosphorylation of complex I subunit NDUFA10 (By similarity).
Gene Ontology	GO:0000287; GO:0000422; GO:0000785; GO:0001934; GO:0002020; GO:0002082; GO:0002931; GO:0004672; GO:0004674; GO:0005524; GO:0005634; GO:0005737; GO:0005739; GO:0005741; GO:0005743; GO:0005758; GO:0005829; GO:0005856; GO:0006468; GO:0006511; GO:0006979; GO:0007005; GO:0010310; GO:0010629; GO:0010821; GO:0010857; GO:0010952; GO:0016020; GO:0016236; GO:0016239; GO:0016242; GO:0016301; GO:0016504; GO:0016567; GO:0018105; GO:0022904; GO:0030424; GO:0030426; GO:0031307; GO:0031396; GO:0031398; GO:0031625; GO:0032148; GO:0032226; GO:0033138; GO:0033603; GO:0034599; GO:0035307; GO:0035556; GO:0036289; GO:0038203; GO:0043123; GO:0043254; GO:0043422; GO:0043524; GO:0044297; GO:0045727; GO:0046329; GO:0048471; GO:0050821; GO:0051091; GO:0051443; GO:0051881; GO:0051897; GO:0055131; GO:0061136; GO:0071456; GO:0072655; GO:0072656; GO:0090141; GO:0090200; GO:0090258; GO:0097237; GO:0097413; GO:0097449; GO:0098779; GO:0099074; GO:1900407; GO:1901727; GO:1902803; GO:1902902; GO:1902958; GO:1903146; GO:1903147; GO:1903202; GO:1903204; GO:1903214; GO:1903298; GO:1903384; GO:1903751; GO:1903852; GO:1903955; GO:1904544; GO:1904783; GO:1904881; GO:2000377; GO:2000378; GO:2001171; GO:2001243

Gene Ontology

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
MARK2 (Q7KZI7)	Homo sapiens	T313	EGLGHGRTLFLVMKN	0.733	0.1137	TP	certain	experimental	66 \| 23 \| 137 \| 31 \| 9 \| 55 \|	22238344	-	-

Interaction Network

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

No KEGG pathways found

No NCI Nature pathways found