| Gene |
NUAK2
|
| Protein Name |
NUAK2_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
NUAK family SNF1-like kinase 2 (EC 2.7.11.1) (Omphalocele kinase 2) (SNF1/AMP kinase-related kinase) (SNARK) |
| Protein Family |
Protein kinase superfamily |
| NCBI Gene ID |
81788
|
| UniProt ID |
Q9H093
|
| Enzyme Class |
2.7.11.1 |
| Molecular Weight |
69612 |
| Protein Length |
628 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
ATP + a protein = ADP + a phosphoprotein. |
| Localization |
N/A |
| Function (UniProt annotation) |
Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95-activated tumor cells. Able to phosphorylate 'Ser-464' of LATS1. |
| Gene Ontology |
GO:0000287; GO:0004674; GO:0005524; GO:0005634; GO:0005737; GO:0006468; GO:0006915; GO:0030036; GO:0035556; GO:0042149; GO:0043066 |
