CaMKinet | Result

Sequence Viewer

Parameter	Value
Gene	MYLK2
Protein Name	MYLK2_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	Myosin light chain kinase 2, skeletal/cardiac muscle (MLCK2) (EC 2.7.11.18)
Protein Family	Protein kinase superfamily
NCBI Gene ID	85366
UniProt ID	Q9H1R3
Enzyme Class	2.7.11.18
Molecular Weight	64685
Protein Length	596
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	ATP + [myosin light-chain] = ADP + [myosin light-chain] phosphate.
Localization	Cytoplasm. Note=Colocalizes with phosphorylated myosin light chain (RLCP) at filaments of the myofibrils.
Function (UniProt annotation)	Implicated in the level of global muscle contraction and cardiac function. Phosphorylates a specific serine in the N-terminus of a myosin light chain.
Gene Ontology	GO:0004683; GO:0004687; GO:0005516; GO:0005524; GO:0005634; GO:0005737; GO:0006941; GO:0007274; GO:0010628; GO:0014816; GO:0018107; GO:0030017; GO:0032027; GO:0032971; GO:0035914; GO:0046777; GO:0055008; GO:0060048

Gene Ontology

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
MAPKAPK2 (P49137)	Homo sapiens	S151	PAFLHSPSCPAIISS	0.943	0.725	-	-	-	-	-	-	-

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

No KEGG pathways found

No NCI Nature pathways found