| Gene |
TXNIP
|
| Protein Name |
TXNIP_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Thioredoxin-interacting protein (Thioredoxin-binding protein 2) (Vitamin D3 up-regulated protein 1) |
| Protein Family |
Arrestin family |
| NCBI Gene ID |
10628
|
| UniProt ID |
Q9H3M7
|
| Enzyme Class |
- |
| Molecular Weight |
43661 |
| Protein Length |
391 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Cytoplasm |
| Function (UniProt annotation) |
May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1). |
| Gene Ontology |
GO:0000122; GO:0004857; GO:0005634; GO:0005737; GO:0005758; GO:0005829; GO:0006606; GO:0007049; GO:0009612; GO:0009749; GO:0030216; GO:0031625; GO:0032355; GO:0032570; GO:0042127; GO:0042542; GO:0043065; GO:0048008; GO:0051592; GO:0051782; GO:0071228 |
