| Gene |
RANBP3
|
| Protein Name |
RANB3_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Ran-binding protein 3 (RanBP3) |
| Protein Family |
N/A |
| NCBI Gene ID |
8498
|
| UniProt ID |
Q9H6Z4
|
| Enzyme Class |
- |
| Molecular Weight |
60210 |
| Protein Length |
567 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Cytoplasm |
| Function (UniProt annotation) |
Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export. |
| Gene Ontology |
GO:0005634; GO:0005643; GO:0005654; GO:0005737; GO:0005813; GO:0006611; GO:0008536; GO:0043547; GO:0070412 |
