| Gene |
RTN4
|
| Protein Name |
RTN4_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
Reticulon-4 (Foocen) (Neurite outgrowth inhibitor) (Nogo protein) (Neuroendocrine-specific protein) (NSP) (Neuroendocrine-specific protein C homolog) (RTN-x) (Reticulon-5) |
| Protein Family |
N/A |
| NCBI Gene ID |
57142
|
| UniProt ID |
Q9NQC3
|
| Enzyme Class |
- |
| Molecular Weight |
129931 |
| Protein Length |
1192 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Endoplasmic reticulum membrane |
| Function (UniProt annotation) |
Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS. Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity). Isoform 2 reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration. Isoform 2 and isoform 3 inhibit BACE1 activity and amyloid precursor protein processing. Induces the formation and stabilization of endoplasmic reticulum (ER) tubules (PubMed:25612671, PubMed:24262037, PubMed:27619977). Regulates membrane morphogenesis in the ER by promoting tubular ER production (PubMed:27619977). Influences NE expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins (PubMed:26906412). |
| Gene Ontology |
GO:0001825; GO:0003723; GO:0005622; GO:0005635; GO:0005783; GO:0005789; GO:0005886; GO:0006915; GO:0007413; GO:0010634; GO:0014069; GO:0021801; GO:0030176; GO:0030308; GO:0030334; GO:0030517; GO:0031625; GO:0033601; GO:0042981; GO:0042995; GO:0043025; GO:0045296; GO:0050771; GO:0050821; GO:0051292; GO:0051897; GO:0060317; GO:0071782; GO:0071786; GO:0071787; GO:0098826; GO:1905552; GO:1905580; GO:1990809; GO:2000172 |
