CaMKinet | Result

Sequence Viewer

Parameter	Value
Gene	METTL1
Protein Name	TRMB_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	tRNA (guanine-N(7)-)-methyltransferase (EC 2.1.1.33) (Methyltransferase-like protein 1) (tRNA (guanine(46)-N(7))-methyltransferase) (tRNA(m7G46)-methyltransferase)
Protein Family	Class I-like SAM-binding methyltransferase superfamily
NCBI Gene ID	4234
UniProt ID	Q9UBP6
Enzyme Class	2.1.1.33
Molecular Weight	31471
Protein Length	276
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.
Localization	Nucleus
Function (UniProt annotation)	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
Gene Ontology	GO:0000049; GO:0005634; GO:0005654; GO:0005730; GO:0005829; GO:0006400; GO:0008176; GO:0030488; GO:0036265; GO:0043527

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
RPS6KA1 (Q15418)	Homo sapiens	S27	YYRQRAHSNPMADHT	0.762	0.4725	-	-	-	-	-	-	In vitro and in vivo

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

No KEGG pathways found

No NCI Nature pathways found