| Gene |
ABCG2
|
| Protein Name |
ABCG2_HUMAN |
| Organism |
Homo sapiens (Human) |
| Alternative name(s) |
ATP-binding cassette sub-family G member 2 (Breast cancer resistance protein) (CDw338) (Mitoxantrone resistance-associated protein) (Placenta-specific ATP-binding cassette transporter) (Urate exporter) (CD antigen CD338) |
| Protein Family |
ABC transporter superfamily |
| NCBI Gene ID |
9429
|
| UniProt ID |
Q9UNQ0
|
| Enzyme Class |
- |
| Molecular Weight |
72314 |
| Protein Length |
655 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Cell membrane |
| Function (UniProt annotation) |
High-capacity urate exporter functioning in both renal and extrarenal urate excretion. Plays a role in porphyrin homeostasis as it is able to mediates the export of protoporhyrin IX (PPIX) both from mitochondria to cytosol and from cytosol to extracellular space, and cellular export of hemin, and heme. Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. Implicated in the efflux of numerous drugs and xenobiotics: mitoxantrone, the photosensitizer pheophorbide, camptothecin, methotrexate, azidothymidine (AZT), and the anthracyclines daunorubicin and doxorubicin. |
| Gene Ontology |
GO:0005215; GO:0005524; GO:0005634; GO:0005886; GO:0006879; GO:0008559; GO:0015232; GO:0015238; GO:0016021; GO:0016324; GO:0031966; GO:0033344; GO:0042493; GO:0042626; GO:0042802; GO:0042803; GO:0043235; GO:0046415; GO:0055085 |
