Parameter | Value |
---|---|
Gene | CEP131 |
Protein Name | CP131_HUMAN |
Organism | Homo sapiens (Human) |
Alternative name(s) | Centrosomal protein of 131 kDa (5-azacytidine-induced protein 1) (Pre-acrosome localization protein 1) |
Protein Family | CEP131 family |
NCBI Gene ID | 22994 |
UniProt ID | Q9UPN4 |
Enzyme Class | - |
Molecular Weight | 122149 |
Protein Length | 1083 |
Protein Domain | InterPro | Pfam |
3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase | SwissModel |
Gene Expression | Gene Expression Atlas |
Function and Disease | OMIM |
Protein-protein Interaction Database | STRING | IntAct | MINT |
Kinase Database | Phospho.ELM | PhosphoSite | NetworKIN |
Catalytic Activity (UniProt annotation) | - |
Localization | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome |
Function (UniProt annotation) | Component of centriolar satellites contributing to the building of a complex and dynamic network required to regulate cilia/flagellum formation (PubMed:17954613, PubMed:24185901). In proliferating cells, MIB1-mediated ubiquitination induces its sequestration within centriolar satellites, precluding untimely cilia formation initiation (PubMed:24121310). In contrast, during normal and ultraviolet or heat shock cellular stress-induced ciliogenesis, its non-ubiquitinated form is rapidly displaced from centriolar satellites and recruited to centrosome/basal bodies in a microtubule- and p38 MAPK-dependent manner (PubMed:24121310, PubMed:26616734). Acts also as a negative regulator of BBSome ciliary trafficking (PubMed:24550735). Plays a role in sperm flagellar formation; may be involved in the regulation of intraflagellar transport (IFT) and/or intramanchette (IMT) trafficking, which are important for axoneme extension and/or cargo delivery to the nascent sperm tail (By similarity). Required for optimal cell proliferation and cell cycle progression; may play a role in the regulation of genome stability in non-ciliogenic cells (PubMed:22797915, PubMed:26297806). Involved in centriole duplication (By similarity). Required for CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). |
Gene Ontology | GO:0000086; GO:0001669; GO:0005813; GO:0005815; GO:0005829; GO:0007275; GO:0007283; GO:0008284; GO:0010389; GO:0010824; GO:0015630; GO:0030154; GO:0034451; GO:0035735; GO:0035869; GO:0042803; GO:0043231; GO:0044877; GO:0045171; GO:0060271; GO:0071539; GO:0090316; GO:0097711 |
Gene Name | Organism | P-Site | Sequence(+/-7) | Conservation | Disorder | Curator Assessment | Reliability | Evidence Class | Evidence Logic | PubMed | Phospho-ELM | PhosphoSite-Plus |
---|---|---|---|---|---|---|---|---|---|---|---|---|
MAPKAPK2 (P49137) | Homo sapiens | S47 | KPIVRSVSVVTGSEQ | 0.844 | 0.712 | - | - | - | - | - | - |
|
MAPKAPK2 (P49137) | Homo sapiens | S78 | NNLRRSNSTTQVSQP | 0.95 | 0.853 | - | - | - | - | - | - |
|
Reactome Pathways
No KEGG pathways found
No NCI Nature pathways found