| Gene |
Foxo3
|
| Protein Name |
FOXO3_MOUSE |
| Organism |
Mus musculus (Mouse) |
| Alternative name(s) |
Forkhead box protein O3 |
| Protein Family |
N/A |
| NCBI Gene ID |
56484
|
| UniProt ID |
Q9WVH4
|
| Enzyme Class |
- |
| Molecular Weight |
71064 |
| Protein Length |
672 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Cytoplasm, cytosol |
| Function (UniProt annotation) |
Transcriptional activator (PubMed:23805378). Triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress (By similarity). Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3' (By similarity). Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation (By similarity). In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription (PubMed:23283301). |
| Gene Ontology |
GO:0000122; GO:0000978; GO:0000981; GO:0001221; GO:0001227; GO:0001228; GO:0001542; GO:0001544; GO:0001547; GO:0001556; GO:0003677; GO:0003700; GO:0005634; GO:0005654; GO:0005737; GO:0005739; GO:0005741; GO:0005759; GO:0005829; GO:0006355; GO:0006357; GO:0006390; GO:0006417; GO:0007568; GO:0008013; GO:0008134; GO:0008286; GO:0016020; GO:0019901; GO:0030330; GO:0030336; GO:0031490; GO:0031667; GO:0032991; GO:0033209; GO:0034246; GO:0034599; GO:0042593; GO:0043065; GO:0043525; GO:0043565; GO:0045648; GO:0045665; GO:0045893; GO:0045944; GO:0048854; GO:0071333; GO:0071386; GO:0071456; GO:0071548; GO:0090090; GO:0097150; GO:0097192; GO:1901300; GO:1903428; GO:1904646; GO:1990090; GO:1990785; GO:2000177; GO:2000353; GO:2000377 |
