CaMKinet | Result

Sequence Viewer

Parameter	Value
Gene	CABIN1
Protein Name	CABIN_HUMAN
Organism	Homo sapiens (Human)
Alternative name(s)	Calcineurin-binding protein cabin-1 (Calcineurin inhibitor) (CAIN)
Protein Family	N/A
NCBI Gene ID	23523
UniProt ID	Q9Y6J0
Enzyme Class	-
Molecular Weight	246352
Protein Length	2220
Protein Domain	InterPro \| Pfam
3D Structure	PDBe \| PDBj \| RCSB PDB \| DrugPort ModBase \| SwissModel
Gene Expression	Gene Expression Atlas
Function and Disease	OMIM
Protein-protein Interaction Database	STRING \| IntAct \| MINT
Kinase Database	Phospho.ELM \| PhosphoSite \| NetworKIN
Catalytic Activity (UniProt annotation)	-
Localization	Nucleus
Function (UniProt annotation)	May be required for replication-independent chromatin assembly. May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin. Inhibition of activated calcineurin is dependent on both PKC and calcium signals. Acts as a negative regulator of p53/TP53 by keeping p53 in an inactive state on chromatin at promoters of a subset of it's target genes.
Gene Ontology	GO:0004864; GO:0005634; GO:0005654; GO:0005829; GO:0006336; GO:0007166; GO:0016235

Gene Name	Organism	P-Site	Sequence(+/-7)	Conservation	Disorder	Curator Assessment	Reliability	Evidence Class	Evidence Logic	PubMed	Phospho-ELM	PhosphoSite-Plus
CAMK4 (Q16566)	Homo sapiens	S2126	PEPSRAKSRPLPNMP	0.526	0.9106	TP	certain	experimental	73 \| 148 \| 72 \| 9 \|	15902271	-	-

Reactome Pathways

Pathway ID	Pathway Name
R-HSA-1280215	Cytokine Signaling in Immune system \| Reactome Pathway
R-HSA-168256	Immune System \| Reactome Pathway
R-HSA-449147	Signaling by Interleukins \| Reactome Pathway
R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling \| Reactome Pathway

No KEGG pathways found

No NCI Nature pathways found