| Gene |
Gab2
|
| Protein Name |
GAB2_MOUSE |
| Organism |
Mus musculus (Mouse) |
| Alternative name(s) |
GRB2-associated-binding protein 2 (GRB2-associated binder 2) (Growth factor receptor bound protein 2-associated protein 2) (PH domain-containing adaptor molecule p97) |
| Protein Family |
GAB family |
| NCBI Gene ID |
N/A
|
| UniProt ID |
Q9Z1S8
|
| Enzyme Class |
- |
| Molecular Weight |
73208 |
| Protein Length |
665 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Cytoplasm |
| Function (UniProt annotation) |
Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis. |
| Gene Ontology |
GO:0005068; GO:0005547; GO:0005737; GO:0005829; GO:0005886; GO:0007229; GO:0008284; GO:0010634; GO:0016477; GO:0019903; GO:0019904; GO:0030316; GO:0032991; GO:0035556; GO:0043306; GO:0043325; GO:0048015 |
