| Gene |
Pikfyve
|
| Protein Name |
FYV1_MOUSE |
| Organism |
Mus musculus (Mouse) |
| Alternative name(s) |
1-phosphatidylinositol 3-phosphate 5-kinase (Phosphatidylinositol 3-phosphate 5-kinase) (EC 2.7.1.150) (FYVE finger-containing phosphoinositide kinase) (PIKfyve) (Phosphatidylinositol 3-phosphate 5-kinase type III) (PIPkin-III) (Type III PIP kinase) (p235) |
| Protein Family |
N/A |
| NCBI Gene ID |
18711
|
| UniProt ID |
Q9Z1T6
|
| Enzyme Class |
2.7.1.150 |
| Molecular Weight |
236877 |
| Protein Length |
2097 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
ATP + 1-phosphatidyl-1D-myo-inositol 3-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3 |
| Localization |
Cytoplasmic vesicle membrane |
| Function (UniProt annotation) |
The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 3,5-bisphosphate. Required for endocytic-vacuolar pathway and nuclear migration. The product of the reaction it catalyzes functions as an important regulator of vacuole homeostasis perhaps by controlling membrane flux to and/or from the vacuole. |
| Gene Ontology |
GO:0000139; GO:0000285; GO:0005524; GO:0005829; GO:0005911; GO:0008270; GO:0010008; GO:0012506; GO:0016308; GO:0030659; GO:0031410; GO:0031901; GO:0031902; GO:0032288; GO:0034504; GO:0035556; GO:0042147; GO:0045121; GO:0048471; GO:0052810; GO:2000785 |
