Protein Name
Death-associated protein kinase 3
UniProt ID
Ensembl Gene ID
NCBI Gene ID
Molecular Weight
51,450
Protein Length
448
Protein Domain
3D Structure
(PDB ID : N/A)
Target by Small Molecules
Protein-protein Interaction Database
Gene Expression
Drugs and Diseases
Enzyme Class
Catalytic Site
Catalytic Activity
ATP + a protein = ADP + a phosphoprotein.
Localization
Nucleus Nucleus, PML body Cytoplasm Cytoplasm, cytoskeleton, microtubule organizing center Chromosome, centromere Cytoplasm, cytoskeleton Note=Predominantly localized to the nucleus. Relocates to the cytoplasm on binding PAWR where the complex appears to interact with actin filaments (Probable). Associated with the centrosomes throughout the mitotic cell cycle, with the centromeres from prophase to anaphase and with the contractile ring during cytokinesis.
Function
Serine/threonine kinase which is involved in the regulation of apoptosis, autophagy, transcription, translation and actin cytoskeleton reorganization. Regulates both type I (caspase-dependent) apoptotic and type II (caspase-independent) autophagic cell deaths signal, depending on the cellular setting. Involved in formation of promyelocytic leukemia protein nuclear body (PML-NB). Involved in apoptosis involving PAWR which mediates cytoplasmic relocation; in vitro phosphorylates PAWR. Phosphorylates MYL12B in non-muscle cells leading to reorganization of actin cytoskeleton such as in regulation of cell polarity and cell migration. Positively regulates canonical Wnt/beta-catenin signaling through interaction with NLK and TCF7L2; disrupts the NLK-TCF7L2 complex thereby influencing the phosphorylation of TCF7L2 by NLK. Phosphorylates RPL13A on 'Ser-77' upon interferon-gamma activation which is causing RPL13A release from the ribosome, RPL13A association with the GAIT complex and its subsequent involvement in transcript-selective translation inhibition (By similarity). Phosphorylates STAT3 and enhances its transcriptional activity (By similarity). Enhances transcription from AR-responsive promoters in a hormone- and kinase-dependent manner. Phosphorylates histone H3 on 'Thr-11' at centromeres during mitosis.
Gene Ontology
GO:0000775; GO:0004674; GO:0005524; GO:0005634; GO:0005737; GO:0005884; GO:0006325; GO:0006915; GO:0007346; GO:0008022; GO:0008360; GO:0016301; GO:0016605; GO:0017048; GO:0017148; GO:0030182; GO:0030335; GO:0035556; GO:0042803; GO:0043065; GO:0043519; GO:0043522; GO:0045121; GO:0046777; GO:0051893; GO:0071346; GO:0090263; GO:0097190; GO:2000249; GO:2001241
