| Gene |
Pawr
|
| Protein Name |
PAWR_RAT |
| Organism |
Rattus norvegicus (Rat) |
| Alternative name(s) |
PRKC apoptosis WT1 regulator protein (Prostate apoptosis response 4 protein) (Par-4) (Transcriptional repressor Par-4-like protein PAWR) |
| Protein Family |
N/A |
| NCBI Gene ID |
64513
|
| UniProt ID |
Q62627
|
| Enzyme Class |
- |
| Molecular Weight |
35866 |
| Protein Length |
332 |
| Protein Domain |
InterPro |
Pfam
|
| 3D Structure |
PDBe |
PDBj |
RCSB PDB |
DrugPort
ModBase |
SwissModel
|
| Gene Expression |
Gene Expression Atlas
|
| Function and Disease |
OMIM |
| Protein-protein Interaction Database |
STRING |
IntAct |
MINT
|
| Kinase Database |
Phospho.ELM
|
PhosphoSite
| NetworKIN
|
| Catalytic Activity (UniProt annotation) |
- |
| Localization |
Cytoplasm |
| Function (UniProt annotation) |
Pro-apoptopic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1 (By similarity). |
| Gene Ontology |
GO:0003779; GO:0005080; GO:0005634; GO:0005737; GO:0005884; GO:0006915; GO:0008157; GO:0009611; GO:0010040; GO:0030424; GO:0032355; GO:0032496; GO:0032516; GO:0043005; GO:0043025; GO:0043065; GO:0043525; GO:0045760; GO:0050965; GO:0050966; GO:0051017; GO:0060450; GO:0071306; GO:0071347; GO:0071372; GO:0071392; GO:0090281; GO:0097202; GO:0098703; GO:1901082; GO:1903238; GO:1904457; GO:2000391 |
